Figure 1. Melatonin synthesis in humans.
| Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
| Journal website https://jem.elmerpub.com |
Review
Volume 15, Number 3, August 2025, pages 69-80
Craniopharyngiomas, Alterations of Melatonin Secretion and Their Implications: A Systematic Review
Figures
Tables
| References | Patients (n) | Controls (n) | Melatonin assessment | Results in patients | Results in controls |
|---|---|---|---|---|---|
| BMI: body mass index; RIA: radioimmunoassay; ELISA: enzyme-linked immunosorbent assay; SD: standard deviation. | |||||
| Muller et al, 2006 [33] (SG) | 79 | 30 | Salivary melatonin by RIA (pg/mL) | BMI < 4 SD: | BMI < 4 SD: |
| Morning: median - 7 | Morning: median - 5 | ||||
| Midday: median - 1 | Midday: median - 1 | ||||
| Evening: median - 1 | Evening: median - 1 | ||||
| Night: median - 12 | Night: median - 18 | ||||
| BMI > 4 SD: | BMI > 4 SD: | ||||
| Morning: median - 3 | Morning: median - 10 | ||||
| Midday: median - 2 | Midday: median - 1 | ||||
| Evening: median - 1 | Evening: median - 1 | ||||
| Night: median - 2 | Night: median - 15 | ||||
| Lipton et al, 2009 [34] (RA) | 3 | Historical data | Plasma melatonin by unspecified methodology (pg/mL) | 24-h levels: | Daytime levels: |
| 2.7 ± 0.07 | 8 - 50 pg/mL | ||||
| 0.82 ± 0.12 | |||||
| 0.61 ± 0.02 | |||||
| Nighttime levels: | Nocturnal levels: | ||||
| 0.84 ± 0.82 | 50 - 60 pg/mL | ||||
| 0.74 ± 0.29 | |||||
| 1.22 ± 1.27 | |||||
| Pickering et al, 2014 [35] (ML) | 15 | 15 | Salivary melatonin by RIA (pg/mL) | 24-h median: 86.2 (35.4 - 249.0) | 24-h median: 52.8 (56.7 - 323.7) |
| Kamara et al, 2023 [36] (AR) | 53 | 0 | Salivary melatonin by ELISA (pg/mL) | DLMO not estimable: 25 patients | Not applicable |
| DLMO estimable: 28 patients | |||||
| References | Confounding | Classification | Selection | Deviations | Missing data | Measurement | Reporting | Overall risk |
|---|---|---|---|---|---|---|---|---|
| Muller et al, 2006 [33] | Moderate | Low | Moderate | Low | Low | Moderate | Moderate | Moderate |
| Lipton et al, 2009 [34] | Serious | Low | Moderate | Serious | Serious | Serious | Serious | Serious |
| Pickering et al, 2014 [35] | Low | Low | Low | Low | Low | Low | Low | Low |
| Kamara et al, 2023 [36] | Low | Low | Low | Low | Low | Low | Low | Low |